C.Open;
 C.Edit;
 (C.FieldByname('SDEF') as TBlobField).LoadFromFile('c:\test.txt');
 C.Post;
 C.ApplyUpdates(0);
 C.Close;

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 Comments

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The problem was with the parameter Unicode string variant conversions to memory buffers under Delphi XE2, and would occur when storing strings in plain BLOB fields.

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 Resolution

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Fixed Problem on 7/20/2012 in version 4.33 build 4

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 Products Affected

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DBISAM VCL Client-Server
DBISAM VCL Client-Server with Source
DBISAM VCL Standard
DBISAM VCL Standard with Source
DBISAM VCL Trial